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|本期目录/Table of Contents|

调控细胞内信号通路对喉癌进行多靶点 精准治疗的设想(PDF)

《医学争鸣》[ISSN:1000-2790/CN:61-1060/R]

期数:
2019年04期
页码:
30-32
栏目:
医学设想
出版日期:
2019-08-26

文章信息/Info

Title:
Precise multi-target treatment of laryngocarcinoma by regulating cell downstream signaling pathway
作者:
徐定远李 倩黄书满王 琳朱优立王广科
(河南省人民医院耳鼻喉头颈外科,河南 郑州 450003)
Author(s):
XU Dingyuan LI Qian HUANG Shuman WANG Lin ZHU Youli WANG Guangke
Department of Otorhinolaryngology Head and Neck Surgery, Henan Provincial People’s Hospital, Zhengzhou 450003, China
关键词:
内皮素信号通路G蛋白偶联受体
Keywords:
endothelin signaling pathway G protein-coupled receptor
分类号:
R766.5
DOI:
10.13276/j.issn.1674-8913.2019.04.006
文献标识码:
A
摘要:
内皮素1/内皮素受体轴(ET 1/ETR轴)对很多恶性肿瘤的发展有调控作用。我们发现ET 1/ETR轴能显 著促进喉癌细胞增殖,但通过何种信号通路引发细胞反应尚不明确。内皮素受体属于G蛋白偶联受体,能将信号 经由G蛋白通路传递到细胞核,最终引发细胞反应;β-arrestin可以作为新的通路进行信号传导。两条通路之间不 仅存在着优势偏向,而且引发的最终生物学效果可能不一致。我们根据前期研究发现及逻辑推理,提出通过调控 ET 1/ETR轴诱发的细胞内信号通路对喉癌进行多靶点精准治疗的设想。
Abstract:
The endothelin 1 (ET 1)/ endothelin receptor (ETR) axis plays an important role in the pathogenesis of most malignant tumors. Our previous study has found that ET 1/ETR axis significantly promotes the proliferation of laryngeal cancer cells. However, the exact signaling pathways and downstream proteins that ultimately trigger cell responses remain elusive. ETR belongs to the G protein-coupled receptor, which can transfer the signal to the nucleus through the G protein channel and eventually induce cell response. Recent evidence reveals that β-arrestin also separately participates in signal transduction as a new signaling pathway. Ligands may preferentially activate only G protein or β-arrestinmediated downstream signaling, and confer different effects finally. Based on our previous founding and logical reasoning, we propose the assumption of precision treatment of the laryngocarcinoma by regulating the cell downstream signaling pathway activated by ET 1/ETR axis.

参考文献/References

[1] Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015[J]. CA Cancer J Clin, 2016, 66(2):115-132.
[2] Brand V, Lehmann C, Umkehrer C, et al. Impact of selective anti-BMP9 treatment on tumor cells and tumor angiogenesis[J]. Mol Oncol, 2016, 10(10):1603-1620.
[3] Zhang ZY, Chen LL, Xu W, et al. Effects of silencing endothelin-1 on invasion and vascular formation in lung cancer[J]. Oncol Lett, 2017, 13(6):4390-4396.
[4] Shi L, Zhou SS, Chen WB, et al. Functions of endothelin 1 in apoptosis and migration in hepatocellular carcinoma[J]. Exp Ther Med, 2017, 13(6):3116-3122.
[5] Bagnato A, Rosano L. Understanding and overcoming chemoresistance in ovarian cancer:emerging role of the endothelin axis[J]. Curr Oncol, 2012, 19(1):36-38.
[6] Teoh JP, Park KM, Wang Y, et al. Endothelin-1/endothelin A receptor-mediated biased signaling is a new player in modulating human ovarian cancer cell tumorigenesis[J]. Cell Signal, 2014, 26(12):2885-2895.
[7] Bologna Z, Teoh JP, Bayoumi AS, et al. Biased G proteincoupled receptor signaling: new player in modulating physiology and pathology[J]. Biomol Ther (Seoul), 2017, 25(1):12-25.
[8] Ormanns S, Neumann J, Horst D, et al. WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear beta-Catenin depend on active PI3K signaling[J]. Oncotarget, 2014, 5(10):2999-3011.
[9] Qi Z, Qi S, Gui l, et al. β-arrestin2 regulates TRAILinduced HepG2 cell apoptosis via the Src-extracellular signal-regulated signaling pathway[J]. Mol Med Rep, 2016, 14(1):263-270.
[10] Maguire JJ. Evidence for biased agonists and antagonists at the endothelin receptors[J]. Life Sci, 2016, 159:30-33.
[11] Chen XT, Pitis P, Liu G, et al. Structure-activity relationships and discovery of G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl) methyl] ({2-[(9R) -9-(pyridin-2-yl)- 6-oxaspiro-
[4.5] decan 9 yl] ethyl}) amine (TRV130), for the treatment of acute severe pain[J]. J Med Chem, 2013, 56(20):8019-8031.

备注/Memo

备注/Memo:
通信作者:王广科。Tel:13598895398, E-mail:13598895398@163.com
作者简介:徐定远。博士后,副主任医师。研究方向:耳鼻喉科基础与临床。Tel:17319783505,E-mail:xdysea@126.com
更新日期/Last Update: 2019-08-26