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|本期目录/Table of Contents|

中枢神经系统孤束核部神经元损伤假说(PDF)

《医学争鸣》[ISSN:1000-2790/CN:61-1060/R]

期数:
2020年01期
页码:
37-41
栏目:
医学假说
出版日期:
2020-02-29

文章信息/Info

Title:
Hypothesis of neuronal damage in nucleus tractus solitarius of central nervous system
作者:
郑 翔1毕文杰
( 1四川大学华西基础医学与法医学院基础医学专业实验室,四川 成都 610041;2成都医学院 人体解剖与组织胚胎学教研室,四川 成都 610500)
Author(s):
ZHENG Xiang1 BI Wenjie2
1Laboratory of Basic Medical Science, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China; 2Department of Human Anatomy, Histology and Embryology, Chengdu Medical College, Chengdu 610500, China
关键词:
2型糖尿病原发高血压中枢神经系统慢性应激杏仁核孤束核
Keywords:
type 2 diabetes mellitus essential hypertension central nervous system chronic stress amygdala nucleus nucleus tractus solitarius
分类号:
R255.4
DOI:
10.13276/j.issn.1674-8913.2020.01.010
文献标识码:
A
摘要:
2型糖尿病和原发高血压是现代社会常见的慢性疾病,二者发病率逐渐升高,大多数患 者的治疗效果并不理想。文章首先总结了两种疾病的共同危险因素,提出以中枢神经系统孤束核神 经元损伤为单一原发环节的假说。在该假说的指导下,进一步阐述了脑在糖代谢和血压调控中的核 心作用,解释了2型糖尿病和原发高血压与各个致病危险因素的关系,为今后这两种常见病的预防和 治疗提供一种新思路。
Abstract:
Type 2 diabetes mellitus and essential hypertension are common chronic diseases in modern society. The incidences of these two diseases are gradually increasing, and the clinical treatment effect of most patients is not satisfactory. The article first summarizes the common risk factors of the two diseases, and proposes the hypothesis that the neuronal damage of the nucleus tractus solitarius in the central nervous system is a single primary link. Under the guidance of this hypothesis, the article further elaborates the central role of brain in glucose metabolism and blood pressure regulation, explains the relationship between the two diseases and their risk factors. The article shed a new light for the prevention and treatment of these two common diseases in the future.

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备注/Memo

备注/Memo:
基金项目:四川省教育厅科研项目(16ZB0280)
通信作者:毕文杰。Tel:18030878820,E-mail:bwj118@163.com
作者简介:郑 翔。博士,高级实验师。研究方向:神经损伤与疾病;生物显微技术。Tel:13551384927,E-mail:jasondf211@163.com
更新日期/Last Update: 2020-03-09