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收缩功能不全性心力衰竭心肌逆向重构:一个尚未解决的难题(PDF)

《医学争鸣》[ISSN:1000-2790/CN:61-1060/R]

期数:
2020年01期
页码:
50-52
栏目:
学术争鸣
出版日期:
2020-02-29

文章信息/Info

Title:
Myocardial reverse remodeling in systolic insufficiency heart failure: a puzzle yet to be solved
作者:
李海嵘陈关良方小丽蔡兴赳许荣丽林慕如
(海南省人民医院心血管内科,海南省临床医学研究院心血管病研究所,海南 海口 570311)
Author(s):
LI Hairong CHEN Guanliang FANG Xiaoli CAI Xingjiu XU Rongli LIN Muru
Cardiovascular Institute, Hainan Clinical Medicine Research Institution, Department of Cardiology, Hainan Provincial People’s Hospital, Haikou 570311, China
关键词:
逆向重构收缩功能不全性心力衰竭生物学特征临床评价
Keywords:
reverse remodeling systolic insufficiency heart failure biological characteristics clinical evaluation
分类号:
R-0
DOI:
10.13276/j.issn.1674-8913.2020.01.013
文献标识码:
A
摘要:
收缩功能不全性心力衰竭心肌逆向重构的发现是心力衰竭治疗领域取得的最大进展之 一,它可能将现有延缓心肌重构过程“消极防御”的治疗模式,转变为加速逆向重构“主动出击” 的治疗模式。然而对于逆向重构确切始动因素却知之甚少,这就造成了一些认识上的争议和矛盾, 主要有:①心力衰竭逆向重构存在差异性生物学特征;②心力衰竭逆向重构临床评价尚无统一判断 标准;③心力衰竭逆向重构有效治疗方案莫衷一是。这些问题有待基础医学研究,甚至是患者临床 试验进一步解决。
Abstract:
The discovery of myocardial reverse remodeling in patients with systolic dysfunctional heart failure is one of the greatest advances in the field of heart failure treatment. It may transform the existing treatment mode of “negative defense” that delays myocardial remodeling into accelerated reverse remodeling. However, little is known about the exact starting factors of reverse remodeling, which has caused some controversies and contradictions in understanding. There are mainly: ①There are different biological characteristics in the reverse remodeling of heart failure; ②There is no unified judgment standard for clinical evaluation in reverse remodeling of heart failure; ③The effective treatment plan for reverse remodeling of heart failure is inconsistent. Further basic medical research, and even further clinical trials of patients are needed to solve the problem.

参考文献/References

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备注/Memo

备注/Memo:
基金项目:国家临床重点专科建设项目(卫办医政函〔2011〕873号)
作者简介:李海嵘。硕士,副主任医师。研究方向:结构性心脏病诊疗。Tel:18789341220,E-mail:lihairong_hainan@163.com
更新日期/Last Update: 2020-03-09